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How does Exotoxin of Pseudomonas affect the liver?
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Default How does Exotoxin of Pseudomonas affect the liver? - 12-25-2008, 01:03 PM

The exotoxin of pseudomonas is composed of an A-B component. The B target site is the liver. Once A attach to a receptor in the liver, the A dissociates. The A then blocks translocation so it inhibits protein synthesis.Since the target site of Exotoxin of Pseudomonas aueroginosa is the liver, what kind of damage/pathology does it do to the liver?Corynebacterium diptheria toxin primary target is the heart, nerves and epithelium. This is because the B component of the A-B diphtheria toxin binds to receptors to those tissues. As such it results to myocarditis, recurrent nerve palsy and pseudomembrane respectively.However, the Pseudomonas toxin wherein the B component primary target is the Liver does not seem to show disease in the liver. Pseudomonas cause cellulitis, pneumonia, septicemia, UTI.The liver having the receptors for the pseudomonas toxin does NOT seem to show directly the cause&effect for its disease process unlike the diptheria.
   
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Default 12-28-2008, 09:27 PM

The exotoxin from Pseudomonas aeruginosa is Exotoxin A (PEA). It inhibits protein synthesis especially in the liver. Injected into mice, it causes liver cell death, which was somehow due to T cells responding to other immunokines like TNF, IL-2 and IL-6, and Interferon-gamma. Neutralization of the TNF prevented this liver cell death. The conclusion from this article says liver damage is possibly due to protein synthesis inhibition and cytokine mediated damage to the hepatocyte
   
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