How does Exotoxin of Pseudomonas affect the liver? -
12-25-2008, 01:03 PM
The exotoxin of pseudomonas is composed of an A-B component. The B target site is the liver. Once A attach to a receptor in the liver, the A dissociates. The A then blocks translocation so it inhibits protein synthesis.Since the target site of Exotoxin of Pseudomonas aueroginosa is the liver, what kind of damage/pathology does it do to the liver?Corynebacterium diptheria toxin primary target is the heart, nerves and epithelium. This is because the B component of the A-B diphtheria toxin binds to receptors to those tissues. As such it results to myocarditis, recurrent nerve palsy and pseudomembrane respectively.However, the Pseudomonas toxin wherein the B component primary target is the Liver does not seem to show disease in the liver. Pseudomonas cause cellulitis, pneumonia, septicemia, UTI.The liver having the receptors for the pseudomonas toxin does NOT seem to show directly the cause&effect for its disease process unlike the diptheria.
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